What Fasting Does to Your Immune Process – Superhero Cells

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What Fasting Does to Your Immune Process – Superhero Cells: Thomas DeLauer

Mobile Regeneration

A analyze from USC located that extended fasting (2-three days) can reset and regenerate the immune process – resulted in the depletion of white blood cells and triggered stem cell-based regeneration of new immune process cells

Located that white blood cells are damaged down in the course of fasting, which in convert forces the stem cells in your system to create extra (one)

Insulin and Immune Health

Individuals with insulin resistance have cells in the course of their bodies that really don’t use insulin successfully – indicates the cells have trouble absorbing glucose, which triggers a buildup of sugar in their blood.

Investigation from the Journal of Immunology located that high stages of insulin reduce a form of immune cell termed regulatory T cells – or Tregs – from performing their career to suppress irritation

T cell, also termed T lymphocyte, form of leukocyte (white blood cell) that is an necessary element of the immune process – originate in the bone marrow and mature in the thymus (2)

Fasting and Insulin

When you speedy for an extended period of time, the fat deposits that have amassed around time grow to be the fuel that cells require to function. As a end result, the sizing of the extra fat droplet will get smaller sized around time.

As the sizing of the lipid droplet in muscle and liver cells lower, people cells grow to be extra responsive to insulin


Autophagy is a pure procedure in which your system eliminates toxic compounds and estrogenic chemical compounds and recycles damaged cell parts

In the brain, upregulation of autophagy is strongly neuroprotective although disruption of autophagy triggers neurodegeneration.

In the liver, upregulation of autophagy raises lipolysis (fat usage) and insulin sensitivity, although disruption of autophagy sales opportunities to prediabetes and metabolic syndrome (three,four)


A analyze seeking at liver cells located that the number of autophagosomes greater three hundred% following 24 hrs of fasting, and a even more thirty% about 48 hrs of fasting – began to drop following 48 hrs (5)

Ketone Creation and Irritation

The system begins, on normal, burning ketones concerning 24-48 hrs of fasting – BHB, in certain, has been located to gain the immune process

A analyze from the Yale School of Medicine located that exposing human immune cells to BHB next 2 days of fasting resulted in a decreased inflammatory reaction

BHB blocks NLRP3 inflammasome by blocking K(+) efflux and lowering ASC oligomerization and speck development – potassium efflux, ASC, and speck development are widespread triggers of NLRP3 (six,seven)

Digestive Health

Fasting functions as a “digestive reset” by giving the digestive tract time to rest from breaking down and absorbing foods and will help it reinforce its mucosal lining – About 65% of the body’s vitality have to be directed to the digestive organs following a food

This decreases intestinal irritation and increases motility – sales opportunities to better nutrient absorption and enhanced bowel motion


one) Fasting triggers stem cell regeneration of damaged, previous immune process | USC Information. (n.d.). Retrieved from
2) New part for insulin: influences immune process as nicely as fat burning capacity. (2014, January thirteen). Retrieved from
three) Small-term fasting induces profound neuronal autophagy. (n.d.). Retrieved from
four) The Profound Advantages of Fasting (and Autophagy) | Synchro. (n.d.). Retrieved from
5) Small-term fasting induces profound neuronal autophagy: Autophagy: Vol six, No six. (n.d.). Retrieved from
six) The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory condition. – PubMed – NCBI. (n.d.). Retrieved from
seven) Can Fasting Battle the Flu or Widespread Chilly? (n.d.). Retrieved from


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  1. Thomas – I was losing weight every day with Intermittent fasting, then I saw one of your videos and tried your drink that you make. (cream of  tartar, apple cider vinegar, pink salt…) I stopped losing weight and for 4 days in a row I maintained my weight, then on the 5th and 6th day I gained a pound each day. I am not trying to put on muscle right now, just trying to cut. I have been drinking the mix after 12 hours of not eating, (doing the Warrior diet.) Any idea why I would be leveling off and gaining weight after introducing your drink? Should I stop drinking it?

  2. Hi,

    I am interested in starting your intermittent fasting program. However I am a competitive swimmer and therefore I would so some cardio, I suppose you could call, sessions which I know is not the best when fasted. I would like to shed some excess fat and build some more lean muscle whilst continuing my swimming. I was just wondering if the program would be able to work with this or would the program not suit me ?

    I have tried messaging and getting a reply from 6packabs but never got a reply in 5 days. I hope you will see this and be able to help.

    Kind regards

  3. Can't thank you enough for all that you do brother! I stumbled onto your channel about 7 weeks ago. I jumped straight into IF and haven't looked back since. Not only have I transformed my body, but my results have inspired so many around me to make the necessary changes also. Never before has scientific research been delivered in a way that could keep my interest until now. Keep up the amazing work. I hope that you and your family continue to receive countless blessings!!

  4. Hi Thomas! I really love your vids and i think theyre great!!

    I heard that you were actually some 200 pounds before and now your jacked!

    Can u make a vid about extra skin and do u have them because u dont look like u do?
    Thx alot

  5. Hello sir
    I'm doing cardio for everyday(burpees and rope skipping)and training any one muscle everyday in gym . Should i lose muscle beacause of everyday cardio or not????
    I know this question must be ask on another video but i need help asap……

  6. Hey Thomas! I've been following you for months and have seen great results!
    Recently I realize something interesting that I'd like you to address.
    First thing I do is go to gym, I come home have a coffee (bullet proof) and fast till 1pm. (At which point I have fasted for about 18 – 20 hours, starting at about 6 or 7 the night before).
    Before I eat I feel great and energized, but after I feel like I need to crash. I get so tired after I eat. And It's all in a keto diet (fried eggs, cheese, avocado, olives, nuts etc.) And my urine strips are turning purple so I know the ketones are definitely there.
    Why do I get so tired after I eat? (Sometimes I don't want to eat knowing it will happen to me).

  7. I’ve been watching your videos for a month or so now and love your scientific approach to staying in shape. I’ve just concluded my first 30 hr fast with a hiit workout and I’m planning on breaking my fast in a few hrs. I’m wondering if I can break my fast with apple cider vinegar and maybe a couple of oranges?

  8. Hi Thomas,
    Dr Pablo here from Atlantis Salud Spa. Our company in Ecuador, in March 2018 will want to employ a KETO Sheff… if you or any of your followers have a great education like you, we will offer a job and accommodation. If your looking for a sea change.. and like to volunteer in our cancer facility. Prove yourself, may become a great full time job, nice home and working conditions.
    Over the next 2 years we will be growing to 50 employees… just putting it out there, keep up the great work. Look forward to a video on KETO and cancer…. God Bless…

  9. Thomas DeLauer thanks for great videos You are makeing. What to do- if i'm interested in bodybuilding and i have to eat 300g carbs a day to keep and maintain muscle mass. How to stay healthy with so many carbs. Maybe it is changing something that i use buckweat as my carbs ?

  10. I've been on a low carb intermittent fasting (16:8) diet since last June now, yet I'm still struggling with the symptoms of a cold that I got in early December (still fatigued and now suffering from post-nasal drip the first time in my life). Also, I take a lot of supplements and herbs that are supposed to boost my immune system and my energy levels, and I do nasal lavage with sea salt and Manuka honey, and gargling with salt water, drinking fresh lemon water, taking probiotics and prebiitics and everything, but nothing seems to help. I wonder why 7 months of doing IF didn't help me with my immune system.

  11. Another great segment. Thanks. I'm curious about timing. I'm doing 16:8 but not every day. I'm wondering if I should change something. I try to fast after I workout so my last meal is after my workout then I'm sleeping and working without breakfast. You had mentioned in another video try 3 to 5 days. Should they be in order or scattered? Also, I try to do a bit of cardio to warm up but maybe I should double my time or extend it further?

  12. Thomas u mentioned in one of your videos where you don't like to spend more than 35 mins in the gym can you make a video of what kind of workouts you do for every part of the body plus show us what kind of workout is best during and not during fast thanks

  13. This is SUCH a great video. Sure, it's about fasting but I feel like a lot of the points you touch on are relevant to those of us who eat low carb and are in ketosis. Like when you talk about low insulin and high BHB. These are things achieved not only by fasting but just by being in nutritional ketosis. Thanks!

  14. Hey Thomas – great content!  Quick question – is MCT oil still the best way to break a fast if you are trying to lose weight, work out 4-5 days a week, and are not trying to get into ketosis?  Also, are you still ranking Splenda over Stevia while fasting?

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